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defined PCOS as a gene-dependent ovarian pathology, characterized by the overproduction of androgens and not uniformly represented by the interaction of genetic propensities with other genetic and environmental factors [49]

EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association

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It has been observed to regulate approximately 4,000 human genes, essentially shifting the gene expression of aged cells to resemble that of younger, healthier cells

it is associated with a higher symptom burden and increased risk for exacerbations [11]

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